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Anti-Csk binding protein antibody [PAG-C1] (STJ16100205)

Anti-Csk binding protein antibody [PAG-C1] (STJ16100205)
Anti-Csk binding protein antibody [PAG-C1] (STJ16100205)

Anti-Csk binding protein antibody [PAG-C1] (STJ16100205)

SKU:

STJ16100205-01

£521.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Mouse
Applications:	IP/WB/IHC-P
Reactivity:	Rat/Cow/Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Csk binding protein is suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	PAG-C1
Conjugation:	Unconjugated
Isotype:	IgG2b
Formulation:	Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration:	1 mg/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	PAG1
Gene ID:	55824
Uniprot ID:	PHAG1_HUMAN
Immunogen:	C-terminal peptide (last 15 amino acids) of human Csk binding protein coupled to KLH.

Tissue Specificity	Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
Post Translational Modifications	Palmitoylated. Phosphorylated by FYN on Tyr-317 in resting T-cells.which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation.which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
Function	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Protein Name	Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 Csk-Binding Protein Transmembrane Adapter Protein Pag Transmembrane Phosphoprotein Cbp
Database Links	Reactome: R-HSA-180292 Reactome: R-HSA-202427
Cellular Localisation	Cell Membrane Single-Pass Type Iii Membrane Protein Present In Lipid Rafts
Alternative Antibody Names	Anti-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 antibody Anti-Csk-Binding Protein antibody Anti-Transmembrane Adapter Protein Pag antibody Anti-Transmembrane Phosphoprotein Cbp antibody Anti-PAG1 antibody Anti-CBP antibody Anti-PAG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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