| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:20-1:50 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CSF1 |
| Gene ID: | 1435 |
| Uniprot ID: | CSF1_HUMAN |
| Immunogen Region: | 33-190 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-190 of human CSF1 (NP_757351.1). |
| Immunogen Sequence: | EEVSEYCSHMIGSGHLQSLQ RLIDSQMETSCQITFEFVDQ EQLKDPVCYLKKAFLLVQDI MEDTMRFRDNTPNAIAIVQL QELSLRLKSCFTKDYEEHDK ACVRTFYETPLQLLEKVKNV FNETKNLLDKDWNIFSKNCN NSFAECSSQDVVTKPDCN |
| Post Translational Modifications | N-glycosylated. Isoform 1: N-glycosylated. Isoform 3: N-glycosylated. O-glycosylated.contains chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1: O-glycosylated. |
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Protein Name | Macrophage Colony-Stimulating Factor 1 Csf-1 M-Csf Mcsf Lanimostim Proteoglycan Macrophage Colony-Stimulating Factor Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-449836 Reactome: R-HSA-6783783 Reactome: R-HSA-8957275 Reactome: R-HSA-9680350 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Processed Macrophage Colony-Stimulating Factor 1: Secreted Extracellular Space |
| Alternative Antibody Names | Anti-Macrophage Colony-Stimulating Factor 1 antibody Anti-Csf-1 antibody Anti-M-Csf antibody Anti-Mcsf antibody Anti-Lanimostim antibody Anti-Proteoglycan Macrophage Colony-Stimulating Factor antibody Anti-Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit antibody Anti-CSF1 antibody |
Information sourced from Uniprot.org