Anti-CRNN antibody (396-495) (STJ111406)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CRNN (396-495) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRNN |
| Gene ID | 49860 |
| Uniprot ID | CRNN_HUMAN |
| Immunogen Region | 396-495 |
| Immunogen Sequence | GETVPGGQAQTGASTESGRQ EWSSTHPRRCVTEGQGDRQP TVVGEEWVDDHSRETVILRL DQGNLHTSVSSAQGQDAAQS EEKRGITARELYSYLRSTKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
Additional Info
| Tissue Specificity | Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). |
| Function | Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways. |
| Protein Name | Cornulin53 Kda Putative Calcium-Binding Protein53 Kda Squamous Epithelial-Induced Stress Protein58 Kda Heat Shock ProteinSquamous Epithelial Heat Shock Protein 53Tumor-Related Protein |
| Database Links | |
| Cellular Localisation | CytoplasmDoes Not Colocalize With Tgm1 |
| Alternative Antibody Names | Anti-Cornulin antibodyAnti-53 Kda Putative Calcium-Binding Protein antibodyAnti-53 Kda Squamous Epithelial-Induced Stress Protein antibodyAnti-58 Kda Heat Shock Protein antibodyAnti-Squamous Epithelial Heat Shock Protein 53 antibodyAnti-Tumor-Related Protein antibodyAnti-CRNN antibodyAnti-C1orf10 antibodyAnti-DRC1 antibodyAnti-PDRC1 antibodyAnti-SEP53 antibody |
Information sourced from Uniprot.org