| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CRNN (396-495) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CRNN |
| Gene ID: |
49860 |
| Uniprot ID: |
CRNN_HUMAN |
| Immunogen Region: |
396-495 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
| Immunogen Sequence: |
GETVPGGQAQTGASTESGRQ EWSSTHPRRCVTEGQGDRQP TVVGEEWVDDHSRETVILRL DQGNLHTSVSSAQGQDAAQS EEKRGITARELYSYLRSTKP |
| Tissue Specificity | Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). |
| Function | Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways. |
| Protein Name | Cornulin53 Kda Putative Calcium-Binding Protein53 Kda Squamous Epithelial-Induced Stress Protein58 Kda Heat Shock ProteinSquamous Epithelial Heat Shock Protein 53Tumor-Related Protein |
| Cellular Localisation | CytoplasmDoes Not Colocalize With Tgm1 |
| Alternative Antibody Names | Anti-Cornulin antibodyAnti-53 Kda Putative Calcium-Binding Protein antibodyAnti-53 Kda Squamous Epithelial-Induced Stress Protein antibodyAnti-58 Kda Heat Shock Protein antibodyAnti-Squamous Epithelial Heat Shock Protein 53 antibodyAnti-Tumor-Related Protein antibodyAnti-CRNN antibodyAnti-C1orf10 antibodyAnti-DRC1 antibodyAnti-PDRC1 antibodyAnti-SEP53 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and RALBP1 knockout (KO) HeLa cells, using [KO Validated] RALBP1 Rabbit polyclonal antibody (STJ25290) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/100410/386853/STJ25290_1__75201.1713156009.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and RALBP1 knockout (KO) HeLa cells, using [KO Validated] RALBP1 Rabbit polyclonal antibody (STJ25290) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")