| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CRMP1 (450-500 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
CRMP1 |
| Gene ID: |
1400 |
| Uniprot ID: |
DPYL1_HUMAN |
| Immunogen Region: |
450-500 aa |
| Specificity: |
Specific for CRMP1. |
| Immunogen: |
A synthetic peptide from aa region 450-500 of human CRMP1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat, mouse and chicken. |
| Post Translational Modifications | Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis. |
| Protein Name | Dihydropyrimidinase-Related Protein 1Drp-1Collapsin Response Mediator Protein 1Crmp-1Inactive DihydropyrimidinaseUnc-33-Like Phosphoprotein 3Ulip-3 |
| Database Links | Reactome: R-HSA-399956 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleCell ProjectionGrowth ConePerikaryonAssociated With Centrosomes And The Mitotic Spindle During MetaphaseColocalizes With Flna And Tubulin In The Central Region Of Drg Neuron Growth ConeFollowing Sema3a Stimulation Of Drg NeuronsColocalizes With F-Actin |
| Alternative Antibody Names | Anti-Dihydropyrimidinase-Related Protein 1 antibodyAnti-Drp-1 antibodyAnti-Collapsin Response Mediator Protein 1 antibodyAnti-Crmp-1 antibodyAnti-Inactive Dihydropyrimidinase antibodyAnti-Unc-33-Like Phosphoprotein 3 antibodyAnti-Ulip-3 antibodyAnti-CRMP1 antibodyAnti-DPYSL1 antibodyAnti-ULIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
