| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/FC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-CRM1 for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R09-7P8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | XPO1 |
| Gene ID: | 7514 |
| Uniprot ID: | XPO1_HUMAN |
| Immunogen: | A synthesized peptide derived from human CRM1 |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. |
| Function | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. |
| Protein Name | Exportin-1Exp1Chromosome Region Maintenance 1 Protein Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-165054Reactome: R-HSA-168333Reactome: R-HSA-2173788Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3769402Reactome: R-HSA-450520Reactome: R-HSA-5663220Reactome: R-HSA-5687128Reactome: R-HSA-68877Reactome: R-HSA-69273Reactome: R-HSA-9634638Reactome: R-HSA-9648025Reactome: R-HSA-9707616Reactome: R-HSA-9768919Reactome: R-HSA-9828806Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmCajal BodyNucleolusLocated In The NucleoplasmCajal Bodies And NucleoliShuttles Between The Nucleus/Nucleolus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-1 antibodyAnti-Exp1 antibodyAnti-Chromosome Region Maintenance 1 Protein Homolog antibodyAnti-XPO1 antibodyAnti-CRM1 antibody |
Information sourced from Uniprot.org