Anti-CREM antibody (81-130 aa) (STJ92471)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CREM at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-cAMP-responsive element modulator (81-130 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CREM |
| Gene ID | 1390 |
| Uniprot ID | CREM_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CREM at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | CREM Polyclonal Antibody detects endogenous levels of CREM protein. |
Additional Info
| Post Translational Modifications | Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro. |
| Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. |
| Protein Name | Camp-Responsive Element ModulatorInducible Camp Early RepressorIcer |
| Database Links | Reactome: R-HSA-400253 Q03060-6 |
| Cellular Localisation | NucleusIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Camp-Responsive Element Modulator antibodyAnti-Inducible Camp Early Repressor antibodyAnti-Icer antibodyAnti-CREM antibody |
Information sourced from Uniprot.org