| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-cAMP-responsive element modulator (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CREM |
| Gene ID: | 1390 |
| Uniprot ID: | CREM_HUMAN |
| Immunogen Region: | 81-130 aa |
| Specificity: | CREM Polyclonal Antibody detects endogenous levels of CREM protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CREM at the amino acid range 81-130 |
| Post Translational Modifications | Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro. |
| Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. |
| Protein Name | Camp-Responsive Element ModulatorInducible Camp Early RepressorIcer |
| Database Links | Reactome: R-HSA-400253 Q03060-6 |
| Cellular Localisation | NucleusIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Camp-Responsive Element Modulator antibodyAnti-Inducible Camp Early Repressor antibodyAnti-Icer antibodyAnti-CREM antibody |
Information sourced from Uniprot.org