| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cyclic AMP-responsive element-binding protein 3-like protein 2 (269-318 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CREB3L2 |
| Gene ID: |
64764 |
| Uniprot ID: |
CR3L2_HUMAN |
| Immunogen Region: |
269-318 aa |
| Specificity: |
CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CREB3L2 at the amino acid range 269-318 |
| Post Translational Modifications | Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). N-glycosylated. Ubiquitinated by HRD1/SYVN1.undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized. |
| Function | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2Camp-Responsive Element-Binding Protein 3-Like Protein 2Bbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinEr Membrane Resident ProteinUpon Er StressTranslocated To The Golgi Apparatus Where It Is CleavedThe Cytosolic N-Terminal Fragment (Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1) Is Transported Into The NucleusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2: NucleusTranslocated Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 2 antibodyAnti-Bbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 antibodyAnti-CREB3L2 antibodyAnti-BBF2H7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
