| Post Translational Modifications | Upon ER stress or DNA damage, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). RIP is induced by TGFB1 and ceramide. N-glycosylated. Ubiquitinated by HRD1/SYVN1.undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L1 is stabilized. |
| Function | Cyclic AMP-responsive element-binding protein 3-like protein 1: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition. Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin. Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation. In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A. Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix. (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1Camp-Responsive Element-Binding Protein 3-Like Protein 1Old Astrocyte Specifically-Induced SubstanceOasis Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1: Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinEr Membrane Resident ProteinUpon Er StressTranslocated To The Golgi Apparatus Where It Is CleavedThe Cytosolic N-Terminal Fragment (Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1) Is Transported Into The NucleusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1: NucleusUpon Er Stress Or Dna DamageTransported Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 1 antibodyAnti-Old Astrocyte Specifically-Induced Substance antibodyAnti-Oasis Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1 antibodyAnti-CREB3L1 antibodyAnti-OASIS antibodyAnti-PSEC0238 antibody |
Information sourced from Uniprot.org
