| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CRB3 |
| Gene ID: |
92359 |
| Uniprot ID: |
CRUM3_HUMAN |
| Immunogen Region: |
1-123 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-123 of human CRB3 (NP_777377.1). |
| Immunogen Sequence: |
MANPGLGLLLALGLPFLLAR WGRAWGQIQTTSANENSTVL PSSTSSSSDGNLRPEAITAI IVVFSLLAALLLAVGLALLV RKLREKRQTEGTYRPSSEEQ FSHAAEARAPQDSKETVQGC LPI |
| Tissue Specificity | Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, and colon. Expressed at high levels in retina, colon and mammary glands. Moderately expressed in liver, spleen, pancreas and prostate. Moderately to weakly expressed in the placenta. Weakly expressed in skeletal muscle and small intestine. |
| Function | Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7. |
| Protein Name | Protein Crumbs Homolog 3 |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9705677 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocalizes Primarily To The Apical Membrane With A Small Fraction In The Upper Part Of Tight Junctions Of Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Crumbs Homolog 3 antibodyAnti-CRB3 antibodyAnti-UNQ588 antibodyAnti-PRO1158 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
