| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Complement receptor type 2 (381-430 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CR2 |
| Gene ID: | 1380 |
| Uniprot ID: | CR2_HUMAN |
| Immunogen Region: | 381-430 aa |
| Specificity: | CD21 Polyclonal Antibody detects endogenous levels of CD21 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human CR2 at the amino acid range 381-430 |
| Function | Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Induces also specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus. |
| Protein Name | Complement Receptor Type 2 Cr2 Complement C3d Receptor Epstein-Barr Virus Receptor Ebv Receptor Cd Antigen Cd21 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Complement Receptor Type 2 antibody Anti-Cr2 antibody Anti-Complement C3d Receptor antibody Anti-Epstein-Barr Virus Receptor antibody Anti-Ebv Receptor antibody Anti-Cd Antigen Cd21 antibody Anti-CR2 antibody Anti-C3DR antibody |
Information sourced from Uniprot.org