Anti-CR2 antibody (300-590) (STJ110705)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CR2 (300-590) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CR2 |
| Gene ID | 1380 |
| Uniprot ID | CR2_HUMAN |
| Immunogen Region | 300-590 |
| Immunogen Sequence | IVTYTCDPDPEEGVNFILIG ESTLRCTVDSQKTGTWSGPA PRCELSTSAVQCPHPQILRG RMVSGQKDRYTYNDTVIFAC MFGFTLKGSKQIRCNAQGTW EPSAPVCEKECQAPPNILNG QKEDRHMVRFDPGTSIKYSC NPGYVLVGEESIQCTSEGVW TPPVPQCKVAACEATGRQLL TKPQHQFVRPDVNSSCGEGY KLSGSVYQECQGTIPWFMEI RLCKEITCPPPPVIYNGAH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human CR2/CD21 (NP_001006659.1). |
Additional Info
| Tissue Specificity | Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. |
| Function | Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus. |
| Protein Name | Complement Receptor Type 2Cr2Complement C3d ReceptorEpstein-Barr Virus ReceptorEbv ReceptorCd Antigen Cd21 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Complement Receptor Type 2 antibodyAnti-Cr2 antibodyAnti-Complement C3d Receptor antibodyAnti-Epstein-Barr Virus Receptor antibodyAnti-Ebv Receptor antibodyAnti-Cd Antigen Cd21 antibodyAnti-CR2 antibodyAnti-C3DR antibody |
Information sourced from Uniprot.org