Anti-CPT1A antibody (520-720) [S7MR] (STJ11103437)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CPT1A (520-720) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CPT1A |
| Gene ID | 1374 |
| Uniprot ID | CPT1A_HUMAN |
| Immunogen Region | 520-720 |
| Immunogen Sequence | WDIPGECQEVIETSLNTANL LANDVDFHSFPFVAFGKGII KKCRTSPDAFVQLALQLAHY KDMGKFCLTYEASMTRLFRE GRTETVRSCTTESCDFVRAM VDPAQTVEQRLKLFKLASEK HQHMYRLAMTGSGIDRHLFC LYVVSKYLAVESPFLKEVLS EPWRLSTSQTPQQQVELFDL ENNPEYVSSGGGFGPVADDG Y |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CPT1A (NP_001867.2). |
Additional Info
| Tissue Specificity | Strong expression in kidney and heart, and lower in liver and skeletal muscle. |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways. |
| Protein Name | Carnitine O-Palmitoyltransferase 1 - Liver IsoformCpt1-LCarnitine O-Palmitoyltransferase I - Liver IsoformCpt ICpti-LCarnitine Palmitoyltransferase 1aSuccinyltransferase Cpt1a |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1989781Reactome: R-HSA-200425 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Carnitine O-Palmitoyltransferase 1 - Liver Isoform antibodyAnti-Cpt1-L antibodyAnti-Carnitine O-Palmitoyltransferase I - Liver Isoform antibodyAnti-Cpt I antibodyAnti-Cpti-L antibodyAnti-Carnitine Palmitoyltransferase 1a antibodyAnti-Succinyltransferase Cpt1a antibodyAnti-CPT1A antibodyAnti-CPT1 antibody |
Information sourced from Uniprot.org