Anti-CPLX2 antibody (1-134) (STJ110085)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CPLX2 (1-134) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CPLX2 |
| Gene ID | 10814 |
| Uniprot ID | CPLX2_HUMAN |
| Immunogen Region | 1-134 |
| Immunogen Sequence | MDFVMKQALGGATKDMGKML GGEEEKDPDAQKKEEERQEA LRQQEEERKAKHARMEAERE KVRQQIRDKYGLKKKEEKEA EEKAALEQPCEGSLTRPKKA IPAGCGDEEEEEEESILDTV LKYLPGPLQDMFKK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1). |
Additional Info
| Tissue Specificity | Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. |
| Function | Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. |
| Protein Name | Complexin-2Complexin IiCpx IiSynaphin-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolPresynapseNucleusPerikaryonTranslocated From The Perikaryon To The Presynaptic Terminals During Maturation Of Neuronal CellsIn Mast CellsCytosol And NucleusBecomes Enriched Near Plasma Membrane Following Stimulation |
| Alternative Antibody Names | Anti-Complexin-2 antibodyAnti-Complexin Ii antibodyAnti-Cpx Ii antibodyAnti-Synaphin-1 antibodyAnti-CPLX2 antibody |
Information sourced from Uniprot.org