| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CPLX1 |
| Gene ID: | 10815 |
| Uniprot ID: | CPLX1_HUMAN |
| Immunogen Region: | 1-134 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX1 (NP_006642.1). |
| Immunogen Sequence: | MEFVMKQALGGATKDMGKML GGDEEKDPDAAKKEEERQEA LRQAEEERKAKYAKMEAERE AVRQGIRDKYGIKKKEEREA EAQAAMEANSEGSLTRPKKA IPPGCGDEVEEEDESILDTV IKYLPGPLQDMLKK |
| Tissue Specificity | Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. |
| Function | Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. |
| Protein Name | Complexin-1Complexin ICpx ISynaphin-2 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642Reactome: R-HSA-888590 |
| Cellular Localisation | CytoplasmCytosolPerikaryonPresynapseEnriched At Synaptic-Releasing Sites In Mature Neurons |
| Alternative Antibody Names | Anti-Complexin-1 antibodyAnti-Complexin I antibodyAnti-Cpx I antibodyAnti-Synaphin-2 antibodyAnti-CPLX1 antibody |
Information sourced from Uniprot.org