| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-CPLA2-zeta (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave bands at approx 55-60kDa and 35kDa in Human Placenta lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in th |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PLA2G4F |
| Gene ID: | 255189 |
| Uniprot ID: | PA24F_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_998765.3 |
| Immunogen Sequence: | QTAEEKAFGDFVINR |
| Function | Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis. In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs). |
| Protein Name | Cytosolic Phospholipase A2 ZetaCpla2-ZetaPhospholipase A2 Group Ivf |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483115 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinMitochondrion |
| Alternative Antibody Names | Anti-Cytosolic Phospholipase A2 Zeta antibodyAnti-Cpla2-Zeta antibodyAnti-Phospholipase A2 Group Ivf antibodyAnti-PLA2G4F antibody |
Information sourced from Uniprot.org
