| Function | Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity. Despite being highly expressed in brown adipose tissue, not required for thermogenesis. |
| Protein Name | Cytochrome C Oxidase Subunit 7a1 - MitochondrialCytochrome C Oxidase Subunit Viia-HeartCytochrome C Oxidase Subunit Viia-HCytochrome C Oxidase Subunit Viia-MuscleCytochrome C Oxidase Subunit Viia-M |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564Reactome: R-HSA-9844594Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 7a1 - Mitochondrial antibodyAnti-Cytochrome C Oxidase Subunit Viia-Heart antibodyAnti-Cytochrome C Oxidase Subunit Viia-H antibodyAnti-Cytochrome C Oxidase Subunit Viia-Muscle antibodyAnti-Cytochrome C Oxidase Subunit Viia-M antibodyAnti-COX7A1 antibodyAnti-COX7AH antibody |
Information sourced from Uniprot.org
