| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV. |
| Protein Name | Cytochrome C Oxidase Subunit 6a2 - MitochondrialCytochrome C Oxidase Polypeptide Via-HeartCoxviahCytochrome C Oxidase Subunit Via-MuscleCox Via-M |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 6a2 - Mitochondrial antibodyAnti-Cytochrome C Oxidase Polypeptide Via-Heart antibodyAnti-Coxviah antibodyAnti-Cytochrome C Oxidase Subunit Via-Muscle antibodyAnti-Cox Via-M antibodyAnti-COX6A2 antibodyAnti-COX6A antibodyAnti-COX6AH antibody |
Information sourced from Uniprot.org
