| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
COX4I2 |
| Gene ID: |
84701 |
| Uniprot ID: |
COX42_HUMAN |
| Immunogen Region: |
1-171 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-171 of human COX4I2 (NP_115998.2). |
| Immunogen Sequence: |
MLPRAAWSLVLRKGGGGRRG MHSSEGTTRGGGKMSPYTNC YAQRYYPMPEEPFCTELNAE EQALKEKEKGSWTQLTHAEK VALYRLQFNETFAEMNRRSN EWKTVMGCVFFFIGFAALVI WWQRVYVFPPKPITLTDERK AQQLQRMLDMKVNPVQGLAS RWDYEKKQWKK |
| Tissue Specificity | Highly expressed in lung. |
| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Protein Name | Cytochrome C Oxidase Subunit 4 Isoform 2 - MitochondrialCytochrome C Oxidase Subunit Iv Isoform 2Cox Iv-2 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 4 Isoform 2 - Mitochondrial antibodyAnti-Cytochrome C Oxidase Subunit Iv Isoform 2 antibodyAnti-Cox Iv-2 antibodyAnti-COX4I2 antibodyAnti-COX4L2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
