Anti-CoREST antibody [R01-3N9] (STJA0036844)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CoREST
General Information
| Short Description | Rabbit monoclonal anti-CoREST for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3N9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RCOR1 |
| Gene ID | 23186 |
| Uniprot ID | RCOR1_HUMAN |
| Immunogen | A synthesized peptide derived from human CoREST |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Protein Name | Rest Corepressor 1Protein Corest |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusUpon Infection By Hsv-1It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Rest Corepressor 1 antibodyAnti-Protein Corest antibodyAnti-RCOR1 antibodyAnti-KIAA0071 antibodyAnti-RCOR antibody |
Information sourced from Uniprot.org