| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
COPS4 |
| Gene ID: |
51138 |
| Uniprot ID: |
CSN4_HUMAN |
| Immunogen Region: |
1-310 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS4 (NP_057213.2). |
| Immunogen Sequence: |
MAAAVRQDLAQLMNSSGSHK DLAGKYRQILEKAIQLSGAE QLEALKAFVEAMVNENVSLV ISRQLLTDFCTHLPNLPDST AKEIYHFTLEKIQPRVISFE EQVASIRQHLASIYEKEEDW RNAAQVLVGIPLETGQKQYN VDYKLETYLKIARLYLEDDD PVQAEAYINRASLLQNESTN EQLQIHYKVCYARVLDYRRK FIEAAQRYNELSYKTIVHES ERLEALKHALHCTILASAG |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 4Sgn4Signalosome Subunit 4Jab1-Containing Signalosome Subunit 4 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleSecretory VesicleSynaptic Vesicle |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 4 antibodyAnti-Sgn4 antibodyAnti-Signalosome Subunit 4 antibodyAnti-Jab1-Containing Signalosome Subunit 4 antibodyAnti-COPS4 antibodyAnti-CSN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
