• Immunohistochemistry analysis of COPS3 in paraffin-embedded rat heart tissue using COPS3 Rabbit monoclonal antibody (STJ11103044) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of COPS3 in paraffin-embedded mouse brain tissue using COPS3 Rabbit monoclonal antibody (STJ11103044) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of COPS3 in paraffin-embedded human lung cancer tissue using COPS3 Rabbit monoclonal antibody (STJ11103044) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Western blot analysis of various lysates using COPS3 Rabbit monoclonal antibody (STJ11103044) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-COPS3 antibody (320-423) [S4MR] (STJ11103044)

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STJ11103044

£146.50 - £639.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-COPS3 (320-423) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COPS3
Gene ID: 8533
Uniprot ID: CSN3_HUMAN
Immunogen Region: 320-423
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-423 of human COPS3 (Q9UNS2).
Immunogen Sequence: QDMASRVQLSGPQEAEKYVL HMIEDGEIFASINQKDGMVS FHDNPEKYNNPAMLHNIDQE MLKCIELDERLKAMDQEITV NPQFVQKSMGSQEDDSGNKP SSYS
Tissue Specificity Widely expressed. Expressed at high level in heart and skeletal muscle.
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein Name Cop9 Signalosome Complex Subunit 3
Sgn3
Signalosome Subunit 3
Jab1-Containing Signalosome Subunit 3
Database Links Reactome: R-HSA-5696394
Reactome: R-HSA-6781823
Reactome: R-HSA-8856825
Reactome: R-HSA-8951664
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cop9 Signalosome Complex Subunit 3 antibody
Anti-Sgn3 antibody
Anti-Signalosome Subunit 3 antibody
Anti-Jab1-Containing Signalosome Subunit 3 antibody
Anti-COPS3 antibody
Anti-CSN3 antibody

Information sourced from Uniprot.org

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