| Host: | Sheep |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Sheep polyclonal anti-Connexin-45 (aa: 354-367) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | Mixed |
| Purification: | Whole serum |
| Dilution Range: | IHC 1:100-1:250 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | GJC1 |
| Gene ID: | 10052 |
| Uniprot ID: | CXG1_HUMAN |
| Immunogen Region: | aa: 354-367 |
| Specificity: | Western blotting of cell membranes of COS cells transiently transfected with cDNA encoding Connexin-45 shows a singular band of molecular weight 47 kDa which is abolished by preincubation with the immunising peptide. No such band is detected in Weste |
| Immunogen: | A synthetic peptide (QAYSHQN NPHGPRE) as part of human Connexin-45 protein (aa: 354-367) conjugated to diphtheria toxoid has been used as the immunogen. |
| Immunogen Sequence: | Human |
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Protein Name | Gap Junction Gamma-1 ProteinConnexin-45Cx45Gap Junction Alpha-7 Protein |
| Database Links | Reactome: R-HSA-112303Reactome: R-HSA-190861 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionGap Junction |
| Alternative Antibody Names | Anti-Gap Junction Gamma-1 Protein antibodyAnti-Connexin-45 antibodyAnti-Cx45 antibodyAnti-Gap Junction Alpha-7 Protein antibodyAnti-GJC1 antibodyAnti-GJA7 antibody |
Information sourced from Uniprot.org
