| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-COMT, Biotinylated (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 28kDa band observed in Human Testis lysates. Recommended concentration: 0.3µg/ml. Primary incubation was 1 hour. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | COMT |
| Gene ID: | 1312 |
| Uniprot ID: | COMT_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000745.1; NP_009294.1 |
| Specificity: | This antibody is expected to recognize. Reported variants represent identical protein: XP_011528193.1, XP_011528191.1, XP_011528192.1, XP_011528189.1, XP_011528190.1 Reported variants represent identical protein: NP_000745.1, NP_001128633.1, NP_00112 |
| Immunogen Sequence: | CQDIIPQLKKKYDVD. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
| Protein Name | Catechol O-Methyltransferase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-379397Reactome: R-HSA-379398Reactome: R-HSA-9679191 |
| Cellular Localisation | Isoform Soluble: CytoplasmIsoform Membrane-Bound: Cell MembraneSingle-Pass Type Ii Membrane ProteinExtracellular Side |
| Alternative Antibody Names | Anti-Catechol O-Methyltransferase antibodyAnti-COMT antibody |
Information sourced from Uniprot.org
