Anti-COMT antibody (51-271 aa) (STJ11106950)

SKU:
STJ11106950

£129.50 - £642.50
Current Stock:
Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: COMT
Gene ID: 1312
Uniprot ID: COMT_HUMAN
Immunogen Region: 51-271 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 51-271 of human COMT. (NP_000745.1).
Immunogen Sequence: MGDTKEQRILNHVLQHAEPG NAQSVLEAIDTYCEQKEWAM NVGDKKGKIVDAVIQEHQPS VLLELGAYCGYSAVRMARLL SPGARLITIEINPDCAAITQ RMVDFAGVKDKVTLVVGASQ DIIPQLKKKYDVDTLDMVFL DHWKDRYLPDTLLLEECGLL RKGTVLLADNVICPGAPDFL AHVRGSSCFECTHYQSFLEY REVVDGLEKAIYKGPGSEAG P
Tissue Specificity Brain, liver, placenta, lymphocytes and erythrocytes.
Post Translational Modifications The N-terminus is blocked.
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Protein Name Catechol O-Methyltransferase
Database Links Reactome: R-HSA-156581
Reactome: R-HSA-379397
Reactome: R-HSA-379398
Reactome: R-HSA-9679191
Cellular Localisation Isoform Soluble: Cytoplasm
Isoform Membrane-Bound: Cell Membrane
Single-Pass Type Ii Membrane Protein
Extracellular Side
Alternative Antibody Names Anti-Catechol O-Methyltransferase antibody
Anti-COMT antibody

Information sourced from Uniprot.org

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