| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COMP (20-160) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COMP |
| Gene ID: |
1311 |
| Uniprot ID: |
COMP_HUMAN |
| Immunogen Region: |
20-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP (NP_000086.2). |
| Immunogen Sequence: |
GQGQSPLGSDLGPQMLRELQ ETNAALQDVRELLRQQVREI TFLKNTVMECDACGMQQSVR TGLPSVRPLLHCAPGFCFPG VACIQTESGARCGPCPAGFT GNGSHCTDVNECNAHPCFPR VRCINTSPGFRCEACPPGYS G |
| Tissue Specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. |
| Function | Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Protein Name | Cartilage Oligomeric Matrix ProteinCompThrombospondin-5Tsp5 |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Cartilage Oligomeric Matrix Protein antibodyAnti-Comp antibodyAnti-Thrombospondin-5 antibodyAnti-Tsp5 antibodyAnti-COMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
