| Short Description : | Rabbit polyclonal anti-COMM domain-containing protein 6 (1-50 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COMMD6 |
| Gene ID: | 170622 |
| Uniprot ID: | COMD6_HUMAN |
| Immunogen: | Synthesized peptide derived from the human COMMD6 at the amino acid range 1-50 |
| Immunogen Region: | 1-50 aa |
| Specificity: | This antibody detects endogenous levels of COMMD6 at Human, Mouse, Rat |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. |
| Protein Name | Comm Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 6 antibodyAnti-COMMD6 antibodyAnti-MSTP076 antibody |
Information sourced from Uniprot.org
