Host: | Rabbit |
Applications: | WB/IHC-P/IF/ICC |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:1000-1:5000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | COL1A1 |
Gene ID: | 1277 |
Uniprot ID: | CO1A1_HUMAN |
Immunogen Region: | 26-161 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-161 of human Collagen I/COL1A1 (NP_000079.2). |
Immunogen Sequence: | GQVEGQDEDIPPITCVQNGL RYHDRDVWKPEPCRICVCDN GKVLCDDVICDETKNCPGAE VPEGECCPVCPDGSESPTDQ ETTGVEGPKGDTGPRGPRGP AGPPGRDGIPGQPGLPGPPG PPGPPGPPGLGGNFAP |
Tissue Specificity | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. |
Post Translational Modifications | Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. |
Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
Protein Name | Collagen Alpha-1(I Chain Alpha-1 Type I Collagen |
Database Links | Reactome: R-HSA-114604 Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-198933 Reactome: R-HSA-2022090 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-3000170 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-3000480 Reactome: R-HSA-430116 Reactome: R-HSA-75892 Reactome: R-HSA-76009 Reactome: R-HSA-8874081 Reactome: R-HSA-8940973 Reactome: R-HSA-8948216 Reactome: R-HSA-9845619 Reactome: R-HSA-9845620 Reactome: R-HSA-9845621 Reactome: R-HSA-9845622 Reactome: R-HSA-9846298 |
Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
Alternative Antibody Names | Anti-Collagen Alpha-1(I Chain antibody Anti-Alpha-1 Type I Collagen antibody Anti-COL1A1 antibody |
Information sourced from Uniprot.org