| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Collagen alpha-1XVII chain (1-80 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COL17A1 |
| Gene ID: | 1308 |
| Uniprot ID: | COHA1_HUMAN |
| Immunogen Region: | 1-80 aa |
| Specificity: | COL17A1 Polyclonal Antibody detects endogenous levels of COL17A1 protein. |
| Immunogen: | Synthesized peptide derived from the human n-ternal COL17A1 at the amino acid range 1-80 |
| Post Translational Modifications | The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544. |
| Function | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Protein Name | Collagen Alpha-1(Xvii Chain 180 Kda Bullous Pemphigoid Antigen 2 Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen 120 Kda Linear Iga Dermatosis Antigen Linear Iga Disease Antigen 1 Lad-1 - 97 Kda Linear Iga Disease Antigen 97 Kda Linear Iga Bullous Dermatosis Antigen 97 Kda Lad Antigen 97-Lad Linear Iga Bullous Disease Antigen Of 97 Kda Labd97 |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1650814 Reactome: R-HSA-198933 Reactome: R-HSA-2022090 Reactome: R-HSA-446107 Reactome: R-HSA-8948216 |
| Cellular Localisation | Cell Junction Hemidesmosome Membrane Single-Pass Type Ii Membrane Protein Localized Along The Plasma Membrane Of The Hemidesmosome 120 Kda Linear Iga Disease Antigen: Secreted Extracellular Space Extracellular Matrix Basement Membrane Exclusively Localized To Anchoring Filaments Localized To The Epidermal Side Of Split Skin 97 Kda Linear Iga Disease Antigen: Secreted Localized In The Lamina Lucida Beneath The Hemidesmosomes |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xvii Chain antibody Anti-180 Kda Bullous Pemphigoid Antigen 2 antibody Anti-Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen antibody Anti-120 Kda Linear Iga Dermatosis Antigen antibody Anti-Linear Iga Disease Antigen 1 antibody Anti-Lad-1 - 97 Kda Linear Iga Disease Antigen antibody Anti-97 Kda Linear Iga Bullous Dermatosis Antigen antibody Anti-97 Kda Lad Antigen antibody Anti-97-Lad antibody Anti-Linear Iga Bullous Disease Antigen Of 97 Kda antibody Anti-Labd97 antibody Anti-COL17A1 antibody Anti-BP180 antibody Anti-BPAG2 antibody |
Information sourced from Uniprot.org