Anti-COL12A1 antibody (1481-1530 aa) (STJ92375)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Collagen XII alpha1 at the amino acid range 1481-1530
General Information
| Short Description | Rabbit polyclonal anti-Collagen alpha-1XII chain (1481-1530 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COL12A1 |
| Gene ID | 1303 |
| Uniprot ID | COCA1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Collagen XII alpha1 at the amino acid range 1481-1530 |
| Immunogen Region | 1481-1530 aa |
| Specificity | COL12A1 Polyclonal Antibody detects endogenous levels of COL12A1 protein. |
Additional Info
| Post Translational Modifications | The triple-helical tail is stabilized by disulfide bonds at each end. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. Isoform 1 O-glycosylation.glycosaminoglycan of chondroitin-sulfate type. |
| Function | Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. |
| Protein Name | Collagen Alpha-1(Xii Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1650814Reactome: R-HSA-2022090Reactome: R-HSA-8948216 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xii Chain antibodyAnti-COL12A1 antibodyAnti-COL12A1L antibody |
Information sourced from Uniprot.org