| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
COBL |
| Gene ID: |
23242 |
| Uniprot ID: |
COBL_HUMAN |
| Immunogen Region: |
1100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1100 to the C-terminus of human COBL (NP_001333371.1). |
| Immunogen Sequence: |
QRPVPKDTSLHSALMEAIHS AGGKDRLRKTAEHTGEGRPA KLSYTEAEGERSALLAAIRG HSGTCSLRKALSAPRTASRF STGTLSNTADARQALMDAIR SGTGAARLRKVPLLV |
| Function | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. |
| Protein Name | Protein Cordon-Bleu |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell ProjectionRuffleRecruited To The Cell Membrane Via Interaction With Pacsin1Colocalizes With The Actin CytoskeletonDetected Throughout The Neuron Cell BodyAs Well As In Axons And Dendrites |
| Alternative Antibody Names | Anti-Protein Cordon-Bleu antibodyAnti-COBL antibodyAnti-KIAA0633 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
