| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNGA4 |
| Gene ID: |
1262 |
| Uniprot ID: |
CNGA4_HUMAN |
| Immunogen Region: |
416-575 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1). |
| Immunogen Sequence: |
ISIINIKGNMSGNRRTANIK SLGYSDLFCLSKEDLREVLS EYPQAQTIMEEKGREILLKM NKLDVNAEAAEIALQEATES RLRGLDQQLDDLQTKFARLL AELESSALKIAYRIERLEWQ TREWPMPEDLAEADDEGEPE EGTSKDEEGRASQEGPPGPE |
| Function | Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-4Cng Channel Alpha-4Cnga4Olfactory Cyclic Nucleotide-Gated Channel Subunit 2Ocnc2 |
| Database Links | Reactome: R-HSA-381753Reactome: R-HSA-5620916 |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-4 antibodyAnti-Cng Channel Alpha-4 antibodyAnti-Cnga4 antibodyAnti-Olfactory Cyclic Nucleotide-Gated Channel Subunit 2 antibodyAnti-Ocnc2 antibodyAnti-CNGA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
