• Western blot analysis of various lysates using CNGA4 Rabbit polyclonal antibody (STJ116919) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-CNGA4 antibody (416-575) (STJ116919)

SKU:
STJ116919

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CNGA4 (416-575) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNGA4
Gene ID: 1262
Uniprot ID: CNGA4_HUMAN
Immunogen Region: 416-575
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
Immunogen Sequence: ISIINIKGNMSGNRRTANIK SLGYSDLFCLSKEDLREVLS EYPQAQTIMEEKGREILLKM NKLDVNAEAAEIALQEATES RLRGLDQQLDDLQTKFARLL AELESSALKIAYRIERLEWQ TREWPMPEDLAEADDEGEPE EGTSKDEEGRASQEGPPGPE
Function Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
Protein Name Cyclic Nucleotide-Gated Cation Channel Alpha-4
Cyclic Nucleotide-Gated Channel Alpha-4
Cng Channel Alpha-4
Cng-4
Cng4
Database Links Reactome: R-HSA-381753
Reactome: R-HSA-5620916
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Cyclic Nucleotide-Gated Cation Channel Alpha-4 antibody
Anti-Cyclic Nucleotide-Gated Channel Alpha-4 antibody
Anti-Cng Channel Alpha-4 antibody
Anti-Cng-4 antibody
Anti-Cng4 antibody
Anti-CNGA4 antibody

Information sourced from Uniprot.org

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