• Western blot analysis of lysate from 293 cells, using CMTM6 Antibody.
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-oophoroma, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • Western blot analysis of 293 cells using CMTM6 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-CMTM6 antibody (131-180 aa) (STJ96673)

SKU:
STJ96673

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CKLF-like MARVEL transmembrane domain-containing protein 6 (131-180 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CMTM6
Gene ID: 54918
Uniprot ID: CKLF6_HUMAN
Immunogen Region: 131-180 aa
Specificity: CMTM6 Polyclonal Antibody detects endogenous levels of CMTM6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CMTM6 at the amino acid range 131-180
Function Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Protein Name Cklf-Like Marvel Transmembrane Domain-Containing Protein 6
Chemokine-Like Factor Superfamily Member 6
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Co-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes
Alternative Antibody Names Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibody
Anti-Chemokine-Like Factor Superfamily Member 6 antibody
Anti-CMTM6 antibody
Anti-CKLFSF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance