Anti-CMKLR1 antibody (221-270 aa) (STJ92262)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CMKLR1 at the amino acid range 221-270
General Information
| Short Description | Rabbit polyclonal anti-Chemerin-like receptor 1 (221-270 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:100-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CMKLR1 |
| Gene ID | 1240 |
| Uniprot ID | CML1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CMKLR1 at the amino acid range 221-270 |
| Immunogen Region | 221-270 aa |
| Specificity | ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein. |
Additional Info
| Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
| Protein Name | Chemerin-Like Receptor 1Chemokine-Like Receptor 1G-Protein Coupled Receptor Chemr23G-Protein Coupled Receptor Dez |
| Database Links | Reactome: R-HSA-373076 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes Efficiently In Response To Rarres2 |
| Alternative Antibody Names | Anti-Chemerin-Like Receptor 1 antibodyAnti-Chemokine-Like Receptor 1 antibodyAnti-G-Protein Coupled Receptor Chemr23 antibodyAnti-G-Protein Coupled Receptor Dez antibodyAnti-CMKLR1 antibodyAnti-CHEMR23 antibodyAnti-DEZ antibody |
Information sourced from Uniprot.org