| Short Description : | Rabbit polyclonal anti-Claspin (10-90 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLSPN |
| Gene ID: | 63967 |
| Uniprot ID: | CLSPN_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Immunogen Region: | 10-90 aa |
| Specificity: | CLSPN Polyclonal Antibody detects endogenous levels of protein. |
| Function | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components. |
| Protein Name | ClaspinHclaspin |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-176187Reactome: R-HSA-5689880Reactome: R-HSA-5693607 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Claspin antibodyAnti-Hclaspin antibodyAnti-CLSPN antibody |
Information sourced from Uniprot.org
