| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLK1 |
| Gene ID: | 1195 |
| Uniprot ID: | CLK1_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2). |
| Immunogen Sequence: | MRHSKRTYCPDWDDKDWDYG KWRSSSSHKRRKRSHSSAQE NKRCKYNHSKMCDSHYLESR SINEKDYHSRRYIDEYRNDY TQGCEPGHRQRDHESRYQNH SSKSSGRSGRSSYKSKHRIH HSTSHRRSHG |
| Tissue Specificity | Endothelial cells. |
| Post Translational Modifications | Autophosphorylates on all three types of residues. |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Protein Name | Dual Specificity Protein Kinase Clk1Cdc-Like Kinase 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Clk1 antibodyAnti-Cdc-Like Kinase 1 antibodyAnti-CLK1 antibodyAnti-CLK antibody |
Information sourced from Uniprot.org