• Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-CLIC5 antibody (156-206 aa) (STJ194928)

SKU:
STJ194928

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chloride intracellular channel protein 5 (156-206 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLIC5
Gene ID: 53405
Uniprot ID: CLIC5_HUMAN
Immunogen Region: 156-206 aa
Specificity: This antibody detects endogenous levels of CLIC5 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human CLIC5 at the amino acid range 156-206
Function In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-). Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.
Protein Name Chloride Intracellular Channel Protein 5
Glutaredoxin-Like Oxidoreductase Clic5
Database Links Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Cellular Localisation Isoform 1: Cytoplasm
Cytoskeleton
Cytoplasm
Cell Cortex
Membrane
Single-Pass Membrane Protein
Apical Cell Membrane
Mitochondrion
Cell Projection
Stereocilium
Associates With The Cortical Actin Cytoskeleton
Localizes To The Apical Region Of Cochlear Hair Cells
At The Base Of The Actin-Rich Hair Bundle
Colocalizes With Podocalyxin At The Apical Cell Membrane In Renal Glomeruli
May Localize To The Centrosome In Lens Epithelial Cells
Exists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain
Isoform 2: Golgi Apparatus
Microtubule Organizing Center
Centrosome
Colocalizes With Akap9 At The Golgi Apparatus As Well As
To A Lesser Extent
The Centrosome
Alternative Antibody Names Anti-Chloride Intracellular Channel Protein 5 antibody
Anti-Glutaredoxin-Like Oxidoreductase Clic5 antibody
Anti-CLIC5 antibody

Information sourced from Uniprot.org

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