Anti-CLIC3 antibody (21-70 aa) (STJ92329)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLIC3 at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Chloride intracellular channel protein 3 (21-70 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLIC3 |
| Gene ID | 9022 |
| Uniprot ID | CLIC3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLIC3 at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | CLIC3 Polyclonal Antibody detects endogenous levels of CLIC3 protein. |
Additional Info
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. |
| Protein Name | Chloride Intracellular Channel Protein 3Glutaredoxin-Like Oxidoreductase Clic3 |
| Database Links | |
| Cellular Localisation | NucleusMembraneSingle-Pass Membrane ProteinCell MembraneCytoplasmSecretedExtracellular SpaceExtracellular MatrixPredominantly NuclearSome Protein Was Found In The CytoplasmExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainSecreted Into The Extracellular Matrix By Activated Fibroblasts |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 3 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic3 antibodyAnti-CLIC3 antibody |
Information sourced from Uniprot.org