| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. |
| Protein Name | C-Type Lectin Domain Family 4 Member EC-Type Lectin Superfamily Member 9Macrophage-Inducible C-Type LectinMincle |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCell ProjectionPhagocytic Cup |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member E antibodyAnti-C-Type Lectin Superfamily Member 9 antibodyAnti-Macrophage-Inducible C-Type Lectin antibodyAnti-Mincle antibodyAnti-CLEC4E antibodyAnti-CLECSF9 antibodyAnti-MINCLE antibodyAnti-UNQ218 antibodyAnti-PRO244 antibody |
Information sourced from Uniprot.org
