| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLEC4D |
| Gene ID: | 338339 |
| Uniprot ID: | CLC4D_HUMAN |
| Immunogen Region: | 39-215 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-215 of human CLEC4D (NP_525126.2). |
| Immunogen Sequence: | CLVTHHNFSRCKRGTGVHKL EHHAKLKCIKEKSELKSAEG STWNCCPIDWRAFQSNCYFP LTDNKTWAESERNCSGMGAH LMTISTEAEQNFIIQFLDRR LSYFLGLRDENAKGQWRWVD QTPFNPRRVFWHKNEPDNSQ GENCVVLVYNQDKWAWNDVP CNFEASRICKIPGTTLN |
| Tissue Specificity | Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. |
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells. |
| Protein Name | C-Type Lectin Domain Family 4 Member D C-Type Lectin Superfamily Member 8 C-Type Lectin-Like Receptor 6 Clec-6 Dendritic Cell-Associated C-Type Lectin 3 Dc-Associated C-Type Lectin 3 Dectin-3 Cd Antigen Cd368 |
| Database Links | Reactome: R-HSA-5621480 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member D antibody Anti-C-Type Lectin Superfamily Member 8 antibody Anti-C-Type Lectin-Like Receptor 6 antibody Anti-Clec-6 antibody Anti-Dendritic Cell-Associated C-Type Lectin 3 antibody Anti-Dc-Associated C-Type Lectin 3 antibody Anti-Dectin-3 antibody Anti-Cd Antigen Cd368 antibody Anti-CLEC4D antibody Anti-CLECSF8 antibody Anti-MCL antibody |
Information sourced from Uniprot.org