| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC4D (39-215) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC4D |
| Gene ID: |
338339 |
| Uniprot ID: |
CLC4D_HUMAN |
| Immunogen Region: |
39-215 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 39-215 of human CLEC4D (NP_525126.2). |
| Immunogen Sequence: |
CLVTHHNFSRCKRGTGVHKL EHHAKLKCIKEKSELKSAEG STWNCCPIDWRAFQSNCYFP LTDNKTWAESERNCSGMGAH LMTISTEAEQNFIIQFLDRR LSYFLGLRDENAKGQWRWVD QTPFNPRRVFWHKNEPDNSQ GENCVVLVYNQDKWAWNDVP CNFEASRICKIPGTTLN |
| Tissue Specificity | Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. |
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells. |
| Protein Name | C-Type Lectin Domain Family 4 Member DC-Type Lectin Superfamily Member 8C-Type Lectin-Like Receptor 6Clec-6Dendritic Cell-Associated C-Type Lectin 3Dc-Associated C-Type Lectin 3Dectin-3Cd Antigen Cd368 |
| Database Links | Reactome: R-HSA-5621480Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member D antibodyAnti-C-Type Lectin Superfamily Member 8 antibodyAnti-C-Type Lectin-Like Receptor 6 antibodyAnti-Clec-6 antibodyAnti-Dendritic Cell-Associated C-Type Lectin 3 antibodyAnti-Dc-Associated C-Type Lectin 3 antibodyAnti-Dectin-3 antibodyAnti-Cd Antigen Cd368 antibodyAnti-CLEC4D antibodyAnti-CLECSF8 antibodyAnti-MCL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
