Anti-Cleaved-MMP17-Q129 antibody (110-159 aa) (STJ90062)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MMP17 at the amino acid range 110-159
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Matrix metalloproteinase-17-Q129 (110-159 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP17 |
| Gene ID | 4326 |
| Uniprot ID | MMP17_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MMP17 at the amino acid range 110-159 |
| Immunogen Region | 110-159 aa |
| Specificity | Cleaved-MMP-17 (Q129) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-17 protein resulting from cleavage adjacent to Q129. |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. |
| Protein Name | Matrix Metalloproteinase-17Mmp-17Membrane-Type Matrix Metalloproteinase 4Mt-Mmp 4Mtmmp4Membrane-Type-4 Matrix MetalloproteinaseMt4-MmpMt4mmp |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Isoform Long: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-17 antibodyAnti-Mmp-17 antibodyAnti-Membrane-Type Matrix Metalloproteinase 4 antibodyAnti-Mt-Mmp 4 antibodyAnti-Mtmmp4 antibodyAnti-Membrane-Type-4 Matrix Metalloproteinase antibodyAnti-Mt4-Mmp antibodyAnti-Mt4mmp antibodyAnti-MMP17 antibodyAnti-MT4MMP antibody |
Information sourced from Uniprot.org