Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Cleaved-Macrophage metalloelastase-G106 (87-136 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | MMP12 |
Gene ID: | 4321 |
Uniprot ID: | MMP12_HUMAN |
Immunogen Region: | 87-136 aa |
Specificity: | Cleaved-MMP-12 (G106) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-12 protein resulting from cleavage adjacent to G106. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human MMP12 at the amino acid range 87-136 |
Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
Protein Name | Macrophage MetalloelastaseMmeMacrophage ElastaseMeHmeMatrix Metalloproteinase-12Mmp-12 |
Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative Antibody Names | Anti-Macrophage Metalloelastase antibodyAnti-Mme antibodyAnti-Macrophage Elastase antibodyAnti-Me antibodyAnti-Hme antibodyAnti-Matrix Metalloproteinase-12 antibodyAnti-Mmp-12 antibodyAnti-MMP12 antibodyAnti-HME antibody |
Information sourced from Uniprot.org