Anti-Cleaved-KLK8-V33 antibody (14-63 aa) (STJ90055)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Neuropsin at the amino acid range 14-63
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Kallikrein-8-V33 (14-63 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLK8 |
| Gene ID | 11202 |
| Uniprot ID | KLK8_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Neuropsin at the amino acid range 14-63 |
| Immunogen Region | 14-63 aa |
| Specificity | Cleaved-KLK8 (V33) Polyclonal Antibody detects endogenous levels of fragment of activated KLK8 protein resulting from cleavage adjacent to V33. |
Additional Info
| Function | Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. |
| Protein Name | Kallikrein-8Hk8NeuropsinNpOvasinSerine Protease 19Serine Protease Tadg-14Tumor-Associated Differentially Expressed Gene 14 Protein |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | SecretedCytoplasmShows A Cytoplasmic Distribution In The Keratinocytes |
| Alternative Antibody Names | Anti-Kallikrein-8 antibodyAnti-Hk8 antibodyAnti-Neuropsin antibodyAnti-Np antibodyAnti-Ovasin antibodyAnti-Serine Protease 19 antibodyAnti-Serine Protease Tadg-14 antibodyAnti-Tumor-Associated Differentially Expressed Gene 14 Protein antibodyAnti-KLK8 antibodyAnti-NRPN antibodyAnti-PRSS19 antibodyAnti-TADG14 antibodyAnti-UNQ283 antibodyAnti-PRO322 antibody |
Information sourced from Uniprot.org