| Tissue Specificity | Liver specific. |
| Post Translational Modifications | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
| Function | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H4Iti Heavy Chain H4Iti-Hc4Inter-Alpha-Inhibitor Heavy Chain 4Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related ProteinIhrpPlasma Kallikrein Sensitive Glycoprotein 120Gp120Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-Iti Heavy Chain H4 antibodyAnti-Iti-Hc4 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 4 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein antibodyAnti-Ihrp antibodyAnti-Plasma Kallikrein Sensitive Glycoprotein 120 antibodyAnti-Gp120 antibodyAnti-Pk-120 Cleaved Into - 70 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 - 35 Kda Inter-Alpha-Trypsin Inhibitor Heavy Chain H4 antibodyAnti-ITIH4 antibodyAnti-IHRP antibodyAnti-ITIHL1 antibodyAnti-PK120 antibodyAnti-PRO1851 antibody |
Information sourced from Uniprot.org
