| Post Translational Modifications | Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated by FAM20C in the extracellular medium. |
| Function | May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H2Iti Heavy Chain H2Iti-Hc2Inter-Alpha-Inhibitor Heavy Chain 2Inter-Alpha-Trypsin Inhibitor Complex Component IiSerum-Derived Hyaluronan-Associated ProteinShap |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 antibodyAnti-Iti Heavy Chain H2 antibodyAnti-Iti-Hc2 antibodyAnti-Inter-Alpha-Inhibitor Heavy Chain 2 antibodyAnti-Inter-Alpha-Trypsin Inhibitor Complex Component Ii antibodyAnti-Serum-Derived Hyaluronan-Associated Protein antibodyAnti-Shap antibodyAnti-ITIH2 antibodyAnti-IGHEP2 antibody |
Information sourced from Uniprot.org
