| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cleaved-Inter-alpha-trypsin inhibitor heavy chain H2-D702 (653-702 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITIH2 |
| Gene ID: | 3698 |
| Uniprot ID: | ITIH2_HUMAN |
| Immunogen Region: | 653-702 aa |
| Specificity: | Cleaved-ITI-H2 (D702) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H2 protein resulting from cleavage adjacent to D702. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ITIH2 at the amino acid range 653-702 |
| Post Translational Modifications | Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated by FAM20C in the extracellular medium. |
| Function | May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
| Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 Iti Heavy Chain H2 Iti-Hc2 Inter-Alpha-Inhibitor Heavy Chain 2 Inter-Alpha-Trypsin Inhibitor Complex Component Ii Serum-Derived Hyaluronan-Associated Protein Shap |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 antibody Anti-Iti Heavy Chain H2 antibody Anti-Iti-Hc2 antibody Anti-Inter-Alpha-Inhibitor Heavy Chain 2 antibody Anti-Inter-Alpha-Trypsin Inhibitor Complex Component Ii antibody Anti-Serum-Derived Hyaluronan-Associated Protein antibody Anti-Shap antibody Anti-ITIH2 antibody Anti-IGHEP2 antibody |
Information sourced from Uniprot.org