Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-ITGA5-Arg894, Heavy Chain antibody (894-895) (STJA0005872)

SKU:
STJA0005872
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Cleaved-Integrin alpha-5-Arg894, Heavy Chain (894-895) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITGA5
Gene ID: 3678
Uniprot ID: ITA5_HUMAN
Immunogen Region: 894-895
Specificity: This antibody detects endogenous levels of Human, Mouse ITGA5 (heavy chain, Cleaved-Arg894, protein was cleaved amino acid sequence between 894-895 )
Immunogen: Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)
Tissue Specificity Expressed in placenta (at protein level).
Post Translational Modifications Proteolytic cleavage by PCSK5 mediates activation of the precursor.
Function Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Protein Name Integrin Alpha-5
Cd49 Antigen-Like Family Member E
Fibronectin Receptor Subunit Alpha
Integrin Alpha-F
Vla-5
Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain
Database Links Reactome: R-HSA-1566948
Reactome: R-HSA-1566977
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-445144
Reactome: R-HSA-8941332
Reactome: R-HSA-9634597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Alternative Antibody Names Anti-Integrin Alpha-5 antibody
Anti-Cd49 Antigen-Like Family Member E antibody
Anti-Fibronectin Receptor Subunit Alpha antibody
Anti-Integrin Alpha-F antibody
Anti-Vla-5 antibody
Anti-Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain antibody
Anti-ITGA5 antibody
Anti-FNRA antibody

Information sourced from Uniprot.org

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