| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XII-R372 (323-372 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F12 |
| Gene ID: |
2161 |
| Uniprot ID: |
FA12_HUMAN |
| Immunogen Region: |
323-372 aa |
| Specificity: |
Cleaved-Factor XII HC (R372) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to R372. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human FA12 at the amino acid range 323-372 |
| Function | Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. |
| Protein Name | Coagulation Factor XiiHageman FactorHaf Cleaved Into - Coagulation Factor Xiia Heavy Chain - Beta-Factor Xiia Part 1 - Coagulation Factor Xiia Light ChainBeta-Factor Xiia Part 2 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9657688Reactome: R-HSA-9657689 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor Xii antibodyAnti-Hageman Factor antibodyAnti-Haf Cleaved Into - Coagulation Factor Xiia Heavy Chain - Beta-Factor Xiia Part 1 - Coagulation Factor Xiia Light Chain antibodyAnti-Beta-Factor Xiia Part 2 antibodyAnti-F12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
