• Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.
  • Western blot analysis of FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.

Anti-Cleaved-F12-I20 antibody (1-50 aa) (STJ90083)

SKU:
STJ90083

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XII-I20 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: F12
Gene ID: 2161
Uniprot ID: FA12_HUMAN
Immunogen Region: 1-50 aa
Specificity: Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FA12 at the amino acid range 1-50
Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Protein Name Coagulation Factor Xii
Hageman Factor
Haf Cleaved Into - Coagulation Factor Xiia Heavy Chain - Beta-Factor Xiia Part 1 - Coagulation Factor Xiia Light Chain
Beta-Factor Xiia Part 2
Database Links Reactome: R-HSA-140837
Reactome: R-HSA-9657688
Reactome: R-HSA-9657689
Cellular Localisation Secreted
Alternative Antibody Names Anti-Coagulation Factor Xii antibody
Anti-Hageman Factor antibody
Anti-Haf Cleaved Into - Coagulation Factor Xiia Heavy Chain - Beta-Factor Xiia Part 1 - Coagulation Factor Xiia Light Chain antibody
Anti-Beta-Factor Xiia Part 2 antibody
Anti-F12 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance