| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XI-Arg387, Heavy Chain (387-388) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F11 |
| Gene ID: |
2160 |
| Uniprot ID: |
FA11_HUMAN |
| Immunogen Region: |
387-388 |
| Specificity: |
This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Arg387, protein was cleaved amino acid sequence between 387-388 ) |
| Immunogen: |
Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Arg387) |
| Tissue Specificity | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
| Post Translational Modifications | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. |
| Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
| Protein Name | Coagulation Factor XiFxiPlasma Thromboplastin AntecedentPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9673221 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor Xi antibodyAnti-Fxi antibodyAnti-Plasma Thromboplastin Antecedent antibodyAnti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibodyAnti-F11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
